HARMONIZATION OF RAIL PROFILES AND WHEEL PAIR

Harmonization of rail profiles and wheel pair

The main difficulty of developing measures for complex evaluation of loading and increasing of resource of running gear parts performance is considering of differences of performance conditions of wheel-rail system.The article presents review of Russian and foreign experience on selection of shapes of carriage wheel profiles depending on the develo

read more


Targeted delivery of oxaliplatin via folate-decorated niosomal nanoparticles potentiates resistance reversion of colon cancer cells

Background: Colorectal cancer (CRC) is a prevalent type of cancer, ranking third in incidence and fourth in cancer-related deaths globally.The increase in mortality rates related to colorectal cancer among younger patients is a cause for concern.Chemotherapy is the primary approach for palliative care in colon cancer, but the development of drug re

read more


Pinus densiflora extract protects human skin fibroblasts against UVB-induced photoaging by inhibiting the expression of MMPs and increasing type I procollagen expression

Exposure to ultraviolet (UV) light can cause skin photoaging, which is associated with upregulation of matrix metalloproteinases (MMPs) and downregulation of collagen synthesis.It has been reported that MMPs, especially MMP-1, MMP-3 and MMP-9, decrease the elasticity of the dermis by degrading collagen.In this study, we assessed the effects of Pinu

read more